Article 15419

Title of the article

STRESS-INDUCED DYNAMICS OF THE ERYTHROCYTES ACID RESISTANCE IN NONHEMATOLOGICAL DISEASES 

Authors

Mikhaylis Aleksandr Aleksandrovich, Head of emergency unit, Nizhny Lomov inter-regional hospital of Penza region (89, Sergeeva street, Nizhny Lomov, Penza region, Russia); postgraduate student, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: patof@mail.ru
Mikulyak Nadezhda Ivanovna, Doctor of medical sciences, professor, head of the sub-department of human physiology, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: normphys@mail.ru
Kinzirskiy Aleksandr Sergeevich, Doctor of medical sciences, professor, principal researcher, National Medical Cardiology Research Center (15A, 3rd Cherepkovskaya street, Moscow, Russia), E-mail: akinz@inbox.ru
Vershinina Ol'ga Dmitrievna, Student, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: poloz@yandex.ru
Volodin Andrey Nikolaevich, Student, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: volodin@mail.ru 

Index UDK

616-092 

DOI

10.21685/2072-3032-2019-4-15 

Abstract

Background. The study of the erythrocytes acid resistance dynamics (ARE) in various diseases non-hematological profile.
Materials and methods. 102 patients of cardiological, pulmonary and urological profiles. ARE was recorded on the day of admission, then every 24 hours for several days. The programs used are Microsoft Excel XP and Statistika 6.0, Student and Wilcoxon-Mann-Whitney criteria.
Results. Тhe greatest increase and duration of finding ARE at an elevated level were observed in Q + myocardial infarction, in asthmatic status, type II crisis and acute pyelonephritis. At maximum figures, ARE lasts for 24–48–72 hours. The presence of complications "shifts" the expected reduction in ARE by 24 hours. The adverse course of the disease is characterized by a progressive increase in ARE.
Conclusions. Nonlinearity, oscillation, cyclicity, phaseness, stereotype, gender and nosological non-specificity are characteristic of stress-induced dynamics of ARE, the direct dependence on the severity of stress, the nature of the course and outcome of the main pathological process was found, what should be regarded as a manifestation of the typical reaction of the erythron system to non-specific damage in the body. 

Key words

stress, the system of erythron, the resistance of erythrocytes, nongematological diseases, damage, standard reaction 

Download PDF
References

1. Selye H. Nature. 1936, no. 4, p. 138.
2. Shashkin A. V., Terskov I. A. Produktsiya i destruktsiya eritrotsitov v organizme [The production and destruction of red blood cells in the body]. Novosibirsk, 1986, 110 p. [In Russian]
3. Dymochkin V. N. Ekologiya i zdorov'e cheloveka: tezisy dokladov mezhregion. nauch.-prakt. konf. (Stavropol', 1999) [Ecology and human health: proceedings of interregional scientific and practical conference (Stavropol, 1999)]. Stavropol, 1999, pp. 126–127. [In Russian]
4. Emel'yanova E. A., Chistyakova L. E. Patofiziologiya vospaleniya: sb. nauch. tr. [Pathophysiology of inflammation: collected articles]. Stavropol, 1978, pp. 19–21. [In Russian]
5. Zarubina E. G. Kazanskiy meditsinskiy zhurnal [Kazan medical journal]. 2002, no. 1, pp. 32–35. [In Russian]
6. Pshennikova M. G. Aktual'nye problemy patofiziologii [Actual problems of pathophysiology]. Moscow: Meditsina, 2001, p. 220. [In Russian]
7. Men'shikov A. K. Laboratornye metody issledovaniya v klinike [Laboratory research methods in the clinic]. Moscow: Meditsina, 1987, 348 p. [In Russian]
8. Meerson F. Z. Adaptatsiya, stress i profilaktika [Adaptation, stress and prevention]. Moscow: Nauka, 1981, 103 p. [In Russian]
9. Mikhaylis A. A. Vestnik RUDN. Ser.: Meditsina [Bulletin of RUDN University. Series: Medicine]. 2009, no. 4, pp. 94–96. [In Russian]
10. Wilder J. Stimulus and response: the law of initial value. Bristol: Wright, 1967, 352 p.
11. Okorokov A. N. Diagnostika bolezney vnutrennikh organov. T. 7. Diagnostika bolezney serdtsa i sosudov [Diagnosis of internal organs diseases. Volume 7. Diagnosis of heart disease and blood vessels]. Moscow: Meditsinskaya literatura, 2003, p. 275. [In Russian]
12. Gorizontov P. D. Patologicheskaya fiziologiya i eksperimental'naya terapiya [Pathological physiology and experimental therapy]. 1981, no. 2, pp. 55–63. [In Russian]
13. Ryazantseva N. V., Novitskiy V. V. Patologicheskaya fiziologiya i eksperimental'naya terapiya [Pathological physiology and experimental therapy]. 2004, no. 5, pp. 53–55. [In Russian]
14. Bessis M. Blood Cells. 1975, no. 1, pp. 409–414.

 

Дата создания: 07.04.2020 13:23
Дата обновления: 13.04.2020 13:02